Synthetic Studies on Echinulin and Related Natural Products. III. : A Total Synthesis of Neoe

Total synthesis of neoechinulin (1) was achieved. 4-(3, 3-Dimethylallyl)-2-nitroaniline (3) was synthesized from N-(3, 3-dimethylallyl)-2-nitroaniline (2) in one step (22% yield) by the acid-catalyzed amino-Claisen rearrangement. The nitroaniline (3) was converted in two steps (..