Cognitive behavioural therapy as an adjunct to pharmacotherapy for primary care based patients with treatment resistant depression：results of the CoBalT randomised controlled trial 认知行为治疗作..

Before this study, no evidence from large-scale randomised controlled trials was available for theeff ectiveness of augmentation of antidepressant medication with CBT as a next-step for patients whose depressionhas not responded to pharmacotherapy. Our study has provided robust evidence that CBT as an adjunct to usual carethat includes antidepressants is an eff ective treatment..