Pharmacokinetic Study of Lapatinib and Capecitabin

Patients and MethodsPatients with previously treated, advanced solid malignancies were eligible. Cohorts of at leastthree patients each received once-daily oral lapatinib (continuous) and capecitabine (twice daily for14 days every 21 days). Doses of lapatinib and capecitabine were escalated based on dose-limitingtoxicities in the first treatment cycle until th..