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Pharmacokinetic investigation of dose proportionality with a 24-hour controlled-release formulation of hydromorphone.doc
Pharmacokinetic investigation of dose proportionality with a 24-hour controlled-release formulation of hydromorphone
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剂量均衡研究(Dose Proportionality Study)_计算生物学_科研数据集.pdf
Twelve healthy male (M) and 12 healthy female (F) human subjects (Sub) completed a four period (Per) crossover study. Each subject followed one of four randomly allocated sequences (Seq) of four oral doses (2.5 mg, 5 mg, 10 mg, 15 mg) of Drug A. A seven day washout period separated each of the single dose administrations.
On each of the single dosing days, blood samples were taken from each of the subjects prior to dosing and at 0.25, 0.5, 0.75, 1, 1.5, 2, 3, 4, 6, 8, and 12 hours postdose. From these measurements, the area under the plasma concentration vs. time curve (AUC) from time 0 hours to infinity (ng議r/mL) and the maximum plasma concentration (Cmax) (ng/mL), were estimated for each of the four doses for each subject. The pharmacokinetic data, to the degree of accuracy as reported by the pharmacokineticist, are shown in Table 4.
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Confidence Interval Criteria for Assessment of Dose Proportionality.pdf
Confidence Interval Criteria for Assessment of Dose Proportionality
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剂量均衡研究-AUC第5部分(Dose Proportionality Study-AUC Part 5)_计算生物学_科研数据集.pdf
Eight healthy human male (M) and eight healthy female (F) subjects (Sub) completed a four period (Per) crossover study. Each subject followed one of four randomly allocated sequences (Seq) of four intravenous (i.v.) doses (500 mg, 1000 mg, 2000 mg, 3000 mg) of Drug A. A seven day washout period separated each of the single dose administrations.
On each of the single dosing days, blood samples were taken from each of the subjects prior to dosing and at 0.25, 0.5, 0.75, 1, 1.5, 2, 4, 6, 8, 12, 18, and 24 hours postdose. These blood samples were assayed for both plasma total drug (Tot) and plasma unbound drug (Un) concentrations. From these assay values, the area under the plasma concentration vs. time curve (AUC) from time 0 hours to infinity (mg r/mL) was estimated for plasma total drug and plasma unbound drug, for each of the four doses for each subject. All AUC data were dose adjusted to the 1000 mg dose level.
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Exercise 6 Dose linearity and dose proportionality.ppt
Exercise 6 Dose linearity and dose proportionality
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Direct Proportionality:直接的比例.ppt
Direct Proportionality:直接的比例直接,比例,帮助,比例
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Wars have limits Proportionality, distinction and …:战争限制比例,区别….pdf
Warshave limits Proportionality, distinction humanetreatmentJ Exploringjustice internationalhumanita
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Dose proportionality.doc
Dose proportionality
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Proportionality WTO Law in Comparative Perspective.pdf
本文介绍了国际贸易组织法律的比较透视 公开国际法的原则 不同的上下文功能标准司法

向豆丁求助:有没有Proportionality?

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