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28
Cell-2016-PAM-Dependent Target DNA Recognition and Cleavage by C2c1 CRISPR-Cas Endonuclease.pdf
Cell-2016-PAM-Dependent Target DNA Recognition and Cleavage by C2c1 CRISPR-Cas EndonucleaseCell-2016-PAM-Dependent Target DNA Recognition and Cleavage by C2c1 CRISPR-Cas EndonucleaseCell-2016-PAM-Dependent Target DNA Recognition and Cleavage by C2c1 CRISPR-Cas Endonuclease
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23
nature24644-Programmable base editing of AT to GC in genomic DNA without DNA cleavage.pdf
nature24644-Programmable base editing of A•T to G•C in genomic DNA without DNA cleavagenature24644-Programmable base editing of A•T to G•C in genomic DNA without DNA cleavagenature24644-Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage
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17
nature22398-Structure of the Cpf1 endonuclease R-loop complex after target DNA cleavage.pdf
nature22398-Structure of the Cpf1 endonuclease R-loop complex after target DNA cleavagenature22398-Structure of the Cpf1 endonuclease R-loop complex after target DNA cleavagenature22398-Structure of the Cpf1 endonuclease R-loop complex after target DNA cleavage
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18
nature20781-Variable chromatin structure revealed by in situ spatially correlated DNA cleavage mapping.pdf
1LEttERdoi:10.1038/nau20781Variablechromatin structure revealed situspatially correlated DNA cleavag
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12
DNA cleavage by type III restriction-modification enzyme EcoP15I is independent of spacer distance between two head to head oriented recognition sites.pdf
DNACleavage TypeIII Restriction-modificationEnzyme EcoP15I SpacerDistancebetween Two Head HeadOrient
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74
Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage.pdf
Current genome-editing technologies introduce doublestranded
(ds) DNA breaks at a target locus as the first step to gene
correction1,2. Although most genetic diseases arise from point
mutations, current approaches to point mutation correction are
inefficient and typically induce an abundance of random insertions
and deletions (indels) at the target locus resulting from the cellular
response to dsDNA breaks1,2. Here we report the development of
‘base editing’, a new approach to genome editing that enables the
direct, irreversible conversion of one target DNA base into another
in a programmable manner, without requiring dsDNA backbone
cleavage or a donor template. We engineered fusions of CRISPR/
Cas9 and a cytidine deaminase enzyme that retain the ability to
be programmed with a guide RNA, do not induce dsDNA breaks,
and mediate the direct conversion of cytidine to uridine, thereby
effecting a C→T (or G→A) substitu
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30
DNA damage-induced cell death relies on SLFN11-dependent cleavage of distinct type II tRNAs.pdf
DNA damage-induced cell death relies on SLFN11-dependent cleavage of distinct type II tRNAs
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